The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines
The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines
Blog Article
IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic, vitamin D has been established as an immune-modulator here that reduces pro-inflammatory damage which effectively diminish the severity of COVID-19.Vitamin D also has a significant effect against influenza and dengue and increase the seroconversion following influenza vaccination.To date, the role of vitamin D in optimizing the efficacy of COVID-19 vaccines remains unclear.
This study aimed to analyze the correlation between serum 25-hydroxy-cholecalciferol or 25(OH)D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients.MethodologyA multicenter cross-sectional study was conducted among solid and hematologic cancer patients who were vaccinated with two doses of the same types of COVID-19 vaccines (either mRNA, non-replicating viral vector, or inactivated) within 6 months.ResultThe median serum 25(OH)D level in 119 cancer patients was 36.
36 [IQR = 30.30] ng/mL.The seropositivity of S-RBD IgG and NAb reached 93.
3 and 94.1%, respectively.The S-RBD IgG level was significantly higher in the sufficient group (median = 414.
07 [1,441.83] AU/mL) than in the deficient group (median = 91.56 [652.
00] AU/mL) (p-value = 0.049).Among non-chemotherapy subjects, the anti-SARS-CoV-2 S-RBD IgG levels had a significant positive correlation with 25(OH)D levels (p-value = 0.
03; R = 0.588).The NAb levels also showed significantly positive correlation with 25(OH)D level (p-value = 0.
005; R = 0.561).The 25(OH)D levels were positively correlated with S-RBD IgG levels among subjects younger than 60 years old (p-value = 0.
047; R = 0.136).However, serum 25 (OH)D levels showed no such correlation with S-RBD IgG levels among subjects older than 60 years old (p-value = 0.
933; R = 0.136).ConclusionBoth anti-SARS-CoV-2 S-RBD IgG and vibrating table for chocolate NAb levels developed moderate correlation with 25(OH)D levels among subjects treated without chemotherapy.
The S-RBD IgG levels also had positive correlation with 25(OH)D levels among subjects younger than 60 years old.Thus, we recommended cancer patients to maintain serum 25(OH)D levels above 30 ng/mL (75 nmol/L) to enhance the efficacy of COVID-19 vaccines.